![]() Septic arthritis is a joint infection that can lead to significant acute and chronic morbidities. The synovial LE test can be used as an accurate test to rapidly rule in or out an acute articular bacterial infection, even in patients with concurrent inflammatory arthritis. The leukocyte esterase strip test can be used as a rapid, bedside method for diagnosing or excluding bacterial infections in different body fluids. Hence, the sensitivity of the synovial LE test was 80.8%, the specificity, PPV, and NPV were 78.6, 70.0, 86.8% respectively based on a positive culture. The LE test results were positive in 30 specimens, trace in 3 and negative in one in the first-time test and were positive in 31 specimens and trace in 3 in the second-time test, while it was negative in all patients with JIA. The mean ages of patients were 64.14 ± 31.27 and 50.88 ± 23.19 months in the JIA group and septic arthritis group, respectively. We compared the result of the synovial LE test with the result of the culture of each patient. We collected the synovial fluid specimens as part of the general diagnostic protocol for patients suspected of Juvenile Idiopathic Arthritis (JIA) or Septic Arthritis (SA). Since this test measures the esterase activity of leukocytes, there is always a dilemma for using this test in patients with inflammatory arthritis. Recently, a synovial leukocyte esterase (LE) test has been used for diagnosing septic arthritis. The process by which joint fluid is removed, arthrocentesis, is only performed in a professional medical setting.The current diagnostic cornerstone for septic arthritis contains gram stains, bacterial culture, and cell count with a differential of aspirated synovial fluid. Synovial fluid analysis cannot be conducted at home. Arthrocentesis is administered by a medical professional who has been trained in the procedure, such as a physician, physician’s assistant, or nurse practitioner. Arthrocentesis is typically performed in the office of the provider who orders the test, or in another medical setting, like a hospital. Synovial fluid analysis is conducted on joint fluid, which is extracted from the joint through a procedure called arthrocentesis. The test may be ordered by your primary care provider, a specialist such as a rheumatologist, who specializes in treating joint diseases, or an orthopedist or orthopedic surgeon, who specializes in bone and connective tissue disorders. Synovial fluid analysis is ordered by a doctor. They can also explain why the benefits of testing outweigh the small risks involved with the procedure. Your doctor can tell you how synovial fluid analysis can confirm or rule out diseases that may be causing your symptoms. Joint fluid analysis is not performed as often in children with joint swelling and pain unless they have symptoms that suggest a joint infection, such as fever and the appearance of being very ill. Joint swelling often referred to as joint effusion.The following symptoms may indicate the need for a synovial fluid analysis: When should I get synovial fluid analysis?Ī synovial fluid analysis may be ordered by your doctor in a number of situations where the cause of joint problems is unknown. A gross assessment can help doctors begin to understand the cause of a patient’s symptoms. Broadly, the tests conducted as part of the synovial fluid analysis fall into three categories: gross assessment, chemical analysis, and microscopic assessment.Ī gross assessment of synovial fluid describes the process in which a doctor examines the synovial fluid for characteristics such as volume, clarity, color, and viscosity. Synovial fluid analysis can consist of several tests which may be performed on the fluid extracted from the joint. Bleeding in the joint: Also called hemarthrosis, an accumulation of blood in the joint can be caused by an injury to the joint, cancer, hemophilia, and other health conditions.Gout or pseudogout: Gout and pseudogout are painful forms of arthritis, caused by the accumulation of uric acid or calcium crystals in the joint.Septic arthritis: Septic arthritis is an infection caused by microbes such as bacteria or fungi that lead to acute inflammation in one or more joints.In some autoimmune disorders, including rheumatoid arthritis, lupus, and psoriatic arthritis, the immune system damages healthy tissues of the joints. Autoimmune disorders: Autoimmune disorders are conditions in which a person’s immune system mistakenly attacks healthy tissue. ![]() ![]() A synovial fluid analysis may be ordered to diagnose or rule out the following conditions: A synovial fluid analysis can help doctors narrow down or diagnose one of the many potential causes of joint pain. The purpose of a synovial fluid analysis is to evaluate the cause of joint pain and inflammation. What is Glucose & Protein- Synovial fluid?
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